Sheep anti EBNA 3A
Catalogue Number: F115P-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | EBNA3A; Epstein Barr Nuclear Antigen 3A |
| Shipping Condition: | RT |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | |
| Application: | ELISA, ICC, IHC-P, WB, IHC-Fr, DB, IB |
Description
Description: EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop
Additional Text
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Western blotting at 0.25-1.00 µg/ml, Dot blotting, ELISA, Immunocytochemistry and Immunohistochemistry on frozen and paraffin embedded tissues. Optimal concentrations must be determined by titration.
Gene ID
5176209
Gene Name
HHV4tp2_gp28
Uniprot ID
Q69138
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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