Biotinylated Human FGFR3 alpha (IIIb) Protein (FGF-HM43BB)
Catalogue Number: FGF-HM43BB-KAT
FGF-HM43BB Image
FGF-HM43BB Image
FGF-HM43BB Image
FGF-HM43BB Image
The purity of Biotinylated Human FGFR3 alpha (IIIb) is greater than 95% as determined by SEC-HPLC.
FGF-HM43BB Image
Biotinylated Human FGFR3 alpha (IIIb) on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
FGF-HM43BB Image
Immobilized Biotinylated Human FGFR3 alpha (IIIb), His Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA.
| Manufacturer: | Kactus |
| Shelf Life: | 24 months |
| Molecular Weight: | The protein has a predicted MW of 41.4 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Protein Kinases |
| Alias: | ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Additional Text
Protein Tag
HIS-AviTag™
Uniprot ID
P22607-2
Short Description
Recombinant Biotinylated Human FGFR3 (IIIb) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Glu23-Gly377.
Storage Note
-20 to -80°C for 24 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biological Activity
Immobilized Biotinylated Human FGFR3 alpha (lllb) at 1Oeg/ml (100Oel/Well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 11.9ng/ml determined by ELISA. See testing image for detail.
Endotoxin
Less than 1 EU per µg by the LAL method.
FGF-HM43BB Datasheet
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