GITRL (Glucocorticoid Induced TNF-Related Ligand, AITRL, Activation-Inducible TNF-Related Ligand, TNFSF18) (PerCP)

Catalogue Number: G2035-15C-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with PerCP.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	11n77
Isotype:	IgG1
Immunogen:	Recombinant protein corresponding to the extracellular domain, Glu52-Ser177, of human glucocorticoid-induced TNF receptor ligand, expressed in Sf-21 cells.
Application:	FC

Overview
Datasheets

Description

Description: Tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily members are regulators of diverse cellular functions such as proliferation, differentiation, and survival/apoptosis. The glucocorticoid-induced TNFR family-related protein (GITR, also known as TNFRSF18 and AITR) is an inducible type I transmembrane protein that modulates T cell survival. The ligand for GITR (GITR Ligand/TNFSF18, also known as AITRL or TL6) is a type II transmembrane protein expressed on endothelial cells, dendritic cells, retinal pigment epithelium and photoreceptor inner segments of the eye, and on stimulated monocytes. Stimulation by LPS and viral infection leads to enhanced expression of GITR Ligand on endothelial cells and antigen presenting cells. Interactions between GITR and GITR Ligand are believed to play a significant role in immunologic tolerance, and immune cell function in the periphery.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

TNFSF18

Uniprot ID

Q9UNG2

Gene ID

8995

Specificity

Recognizes human GITRL.

Purification

Protein G purified

Antibody Clonality

Monoclonal

G2035-15C Datasheet

Price

£832.00

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