GLUT 4 (Glucose Transporter 4, Glucose Transporter Type 4 Insulin-responsive, GLUT4, GLUT-4, Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 4, SLC2A4)

Catalogue Number: G3900-50L-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	11C104
Isotype:	IgG1
Immunogen:	Recombinant corresponding to rat glut-4, Cytoplasmic domain.
Application:	FC, WB

Overview
Datasheets

Description

Description: Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1 to Glut-13, Mol. Wt. 40-80kD) and Sodium glucose co-transporter- 1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue- specific targeting. Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. Glut-1 mediates glucose transport into red cells, and throughout the blood brain barrier, and supply glucose to most cells. Glut-2 provides glucose to the liver and pancreatic cells. Glut-3 is the main transporter in neurons, whereas Glut-4 (mouse/human 509aa) is primarily expressed in muscle and adipose tissue and regulated by insulin.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes rat Glut-4.

Purification

Affinity Purified

Antibody Clonality

Monoclonal

G3900-50L Datasheet

Price

£741.00

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