Anti-Human GITR (Clone 110416)

Catalogue Number: G678-LET

Manufacturer:	Leinco Technologies, Inc
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	RT
Unit(s):	500 ug
Host name:
Clone:	110416
Isotype:
Immunogen:
Application:	ELISA, FC, WB, NT

Overview

Description

Description: GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies. GITR ligand interferes with the suppressor activity of CD4(+) CD25(+) regulatory T-cells.2

Additional Text

Antibody Clonality

Monoclonal

Storage Note

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

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