Glycogen Synthase Kinase 3 alpha (GSK3a) (Agarose)
Catalogue Number: G8170-40P-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in 100mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 Tests |
| Host name: | Mouse |
| Clone: | SBGSK3a4 |
| Isotype: | IgG2a |
| Immunogen: | |
| Application: | IP, WB |
Description
Description: Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3alpha and GSK-3beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes human GSK3a. Species Crossreactivity: Mouse and rat.
Purification
Purified
Antibody Clonality
Monoclonal
G8170-40P Datasheet
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