Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc (GCR-HM10NB)
Catalogue Number: GCR-HM10NB-KAT
| Manufacturer: | Kactus |
| Shelf Life: | 6 months |
| Molecular Weight: | The protein has a predicted MW of 66.9 kDa. |
| Physical state: | Liquid |
| Type: | Protein - Conjugated |
| Alias: | Glucagon receptor; GL-R; GCGR; Glucagon R |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug |
Description
Description: The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
Additional Text
Gene ID
2642
Gene Name
GCGR
Uniprot ID
P47871
Protein Tag
HIS Tag
Storage Note
Valid for 6 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Phe477.
GCR-HM10NB Datasheet
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