Biotinylated Human GPRC5D Protein-VLP (GPR-HM05PB)
Catalogue Number: GPR-HM05PB-KAT
GPR-HM05PB Image
GPR-HM05PB Image
GPR-HM05PB Image
GPR-HM05PB Image
Biotinylated Human GPRC5D VLP captured on CM5 Chip via Streptavidin can bind Anti-GPRC5D Antibody with an affinity constant of 0.28 nM as determined in SPR assay (Biacore T200).
GPR-HM05PB Image
Immobilized Biotinylated Human GPRC5D VLP at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA (QC Test).
GPR-HM05PB Image
The purity of Biotinylated Human GPRC5D VLP is greater than 95% as determined by SEC-HPLC.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The target protein has a predicted MW of 39.6 kDa. |
| Physical state: | Liquid |
| Type: | Protein - Conjugated |
| Alias: | GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug |
Description
Description: Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein-coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.
Additional Text
Uniprot ID
Q9NZD1-1
Storage Note
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Biotinylated Human GPRC5D Protein-VLP is expressed from HEK293.It contains Met1-Val345 (It may have cross reaction with anti-His antibody).
GPR-HM05PB Datasheet
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