CD40 antibody [5C3]
Catalogue Number: GTX00875-GTX
GTX00875 Image
GTX00875 Image
GTX00875 Image
ICC/IF analysis of MCF-7 cells using GTX00875 CD40 antibody [5C3]. Fixation : 4% PFA Permeabilization : 0.25% Triton X-100 Dilution : 1:100
GTX00875 Image
FACS analysis of monocyte-derived dendric cells from healthy adult donor using GTX00875 CD40 antibody [5C3]. Solid line : Primary antibody Broken line : Isotype control
| Manufacturer: | GeneTex |
| Preservative: | no preservative|No preservative |
| Molecular Weight: | 31 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CD40 molecule , Bp50 , CD40 , CDW40 , TNFRSF5 , p50 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 5C3 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant extracellular domain of CD40 |
| Application: | FC, ICC, IF, IHC-Fr, Act |
Description
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Additional Text
Gene ID
958
Uniprot ID
P25942
Purification
Purified
Gene Name
CD40
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Concentration
1 mg/ml
Application Notes
ICC/IF: 1:100. IHC-Fr: 1:100. Activation: 20 µg /ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX00875 Datasheet
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PRODUCT
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DELIVERY
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