Human PD-L1 protein, mouse IgG1 Fc tag (active)

Catalogue Number: GTX01279-PRO-GTX

Manufacturer:	GeneTex
Physical state:	Lyophilized
Type:	Immune Checkpoint Proteins
Alias:	B7-H,B7H1,PD-L1,PDCD1L1,PDCD1LG1,PDL1
Host Cell:	HEK293 cells
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Application:	FA

Overview
Datasheets

Description

Description: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Additional Text

Accession Number

NP_054862.1

Uniprot ID

Q9NZQ7

Gene ID

29126

Gene Name

CD274

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

1. Measured by its binding ability in a functional ELISA. Immobilized recombinant Human PD1-His protein at 10 µg/ml (100 µl/well) can bind Human PD-L1 protein (active) (GTX01279-pro) with a linear range of 1.28-20 µg/ml. 2. Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T cell lymphocytes. The ED₅₀ for this effect is typically 0.4-3 µg/ml.

Protein Tag

Fc Tag, mIgG1 Fc Tag

Storage Note

Store at -20C or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

GTX01279-PRO Datasheet

Price

£257.00

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Quantity
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