CD3 antibody [17A2] (APC-Cy7)

Catalogue Number: GTX01458-15-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rat
Clone:	17A2
Isotype:	IgG2b
Immunogen:
Application:	FC

Overview
Datasheets

Additional Text

Concentration

0.2 mg/ml

Purification

Affinity Purified

Antibody Clonality

Monoclonal

UniProt ID

P04235, P11942, P22646, P24161

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Gene Name

Cd247, Cd3d, Cd3e, Cd3g

Application Notes

*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Specificity

CD3 antigen, delta polypeptide , CD3 antigen, epsilon polypeptide , CD3 antigen, gamma polypeptide , CD247 antigen , T3d , AI504783 , CD3 , CD3epsilon , T3e , Ctg-3 , Ctg3 , T3g , 4930549J05Rik , A430104F18Rik , AW552088 , Cd3 , Cd3-eta , Cd3-zeta , Cd3h , Cd3z , Cd3zeta , T3z , Tcrk , Tcrz

Gene ID

12500; 12501; 12502; 12503

Short Description

The 17A2 antibody reacts with the mouse CD3 complex, comprised of CD3 epsilon, CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 17A2 antibody is a widely used phenotypic marker for mouse T cells. In addition, as the CD3e chain within the TCR complex contains intracellular signaling domains, binding of 17A2 antibody to CD3 can induce cell activation (use format suitable for functional assays).

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

GTX01458-15 Datasheet

GTX01458-15 Reference

Price

£220.00

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