CD8 antibody [SK1] (FITC)

Catalogue Number: GTX01468-06-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CD8 , CD8A , CD8a molecule , Leu2 , MAL , p32 , CD8 alpha , CD8B , CD8B1 , CD8b molecule , LEU2 , LY3 , LYT3 , P37 , CD8 beta
Shipping Condition:	Blue Ice
Unit(s):	100 tests
Host name:	Mouse
Clone:	SK1
Isotype:	IgG1
Immunogen:
Application:	FC

Overview
Datasheets

Additional Text

Purification

Affinity Purified

Concentration

0.025 mg/mL

Uniprot ID

P01732, P10966

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Gene Name

CD8A, CD8B

Gene ID

925; 926

Short Description

The SK1 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The SK1 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. It is cross-reactive with CD8 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus. If used together with an alternative Anti-Human CD8a clone, RPA-T8, the SK1 antibody will not block binding of RPA-T8 to CD8a.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

Application Notes

FCM: 0.125 µg (5 µl) for 10⁵-10⁸ cells in 100 µl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX01468-06 Datasheet

GTX01468-06 Reference

Price

£302.00

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