Human EPO protein (active)
Catalogue Number: GTX03793-PRO-GTX
| Manufacturer: | GeneTex |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | erythropoietin , DBAL , ECYT5 , EP , MVCD2 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 ug |
| Application: | FA |
Description
Description: This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
Additional Text
Gene Name
EPO
Gene ID
2056
Uniprot ID
P01588
Short Description
The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50 < 0. 2ng/mL, corresponding to a specific activity of >5000000 Unit/mg.
Storage Note
Store at -20C or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20C or below. Avoid freeze-thaw cycles.
GTX03793-PRO Datasheet
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