Bestrophin 1 antibody
Catalogue Number: GTX04928-GTX
GTX04928 Image
GTX04928 Image
GTX04928 Image
GTX04928 Image
FACS analysis of live intact Jurkat cells using GTX04928 Bestrophin 1 antibody. Green line : Primary antibody Black line : Control Dilution : 1:20
GTX04928 Image
IHC-P analysis of rat lung tissue using GTX04928 Bestrophin 1 antibody. BEST1 is expressed both in the respiratory epithelium (red arrows) and in vascular smooth muscle (black arrows). Dilution : 1:100
GTX04928 Image
WB analysis of various samples using GTX04928 Bestrophin 1 antibody prior incubated with (Lane 3-4) or without (Lane 1-2) blocking peptide. Lane 1 and Lane 3: rat lung tissue lysate Lane 2 and lane 4 : rat eye tissue lysate Dilution : 1:200
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide |
| Molecular Weight: | 64 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | ARB,BEST,BEST1,BMD,RP50,TU15B,VMD2,bestrophin 1,Bestrophin 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide (C)NPNKDYPGHEMD, corresponding to amino acid residues 259-270 of mouse Bestrophin-1 (Accession O88870) of 3rd extracellular loop |
| Application: | FC, ICC, IF, IHC-P, IP, WB, LCImg |
Description
Description: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
Additional Text
Concentration
0.8 mg/ml
Gene Name
Best1
Purification
Affinity Purified
Molecular Weight
64
Antibody Clonality
Polyclonal
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Gene ID
24115
Uniprot ID
O88870
GTX04928 Datasheet
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