Her3 / ErbB3 antibody

Catalogue Number: GTX100256-GTX

Manufacturer:	GeneTex
Preservative:	0.025% ProClin 300
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	erb-b2 receptor tyrosine kinase 3 , ErbB-3 , FERLK , HER3 , LCCS2 , MDA-BF-1 , c-erbB-3 , c-erbB3 , erbB3-S , p180-ErbB3 , p45-sErbB3 , p85-sErbB3
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Her3 / ErbB3. The exact sequence is proprietary.
Application:	WB

Overview
Datasheets

Description

Description: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Additional Text

Gene Name

ERBB3

Gene ID

2065

Uniprot ID

P21860

Purification

Affinity Purified

Molecular Weight

148

Concentration

2.06 mg/ml

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX100256 Datasheet

Price

£285.00

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