beta Catenin antibody [N1N2-2], N-term
Catalogue Number: GTX101435-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.025% ProClin 300 |
| Physical state: | Liquid |
| Type: | ChIP Validated Antibodies |
| Alias: | catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant protein encompassing a sequence within the N-terminus region of human beta Catenin. The exact sequence is proprietary. |
| Application: | FACS, ICC, IF, IHC-P, IP, ChIP, WB, IHC-Fr, IHC, IHC-WM |
Description
Description: Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]
Additional Text
Gene Name
CTNNB1
Gene ID
1499
Uniprot ID
P35222
Purification
Affinity Purified
Molecular Weight
85
Concentration
0.07 mg/ml
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
Beta-catenin antibody recognizes beta-catenin protein, which acts as a cell adhesion factor as well as an effector of Wnt signaling pathway-driven transcription. Mutation or dysregulation of beta-catenin is associated with many diseases, including developmental disorders and cancers. There are a plethora of commercially available beta-catenin antibodies, among which GeneTex's beta-catenin antibody (GTX101435) is one of the most rigorously validated and widely cited for a number of applications.
GTX101435 Datasheet
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