Pro-MBP / htPAPP-A antibody [5H9]
Catalogue Number: GTX10191-GTX
GTX10191 Image
GTX10191 Image
Detection of human PAPP-A and proMBP subunits of htPAPP-A by monoclonal antibodies in Western blot. Lane 1: PAPP A antibody [18A10] (GTX10196); Lane 2: PAPP A antibody [3C8] (GTX10194); Lane 3: PAPP A antibody [5H9] (GTX10191); Lane 4: PAPP A antibody [11E4] (GTX14597); Lane 5: PAPP A antibody [10A5] (GTX10193); Lane 6: PAPP A antibody [3C8] (GTX10194); Lanes 1-4: reducing conditions; Lanes 5-6: non-reducing conditions, heterotetrameric complex was detected by PAPP A antibody [10A5] (GTX10193) and PAPP A antibody [3C8] (GTX10194)
| Manufacturer: | GeneTex |
| Preservative: | 0.09% Sodium azide |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | pappalysin 1 , ASBABP2 , DIPLA1 , IGFBP-4ase , PAPA , PAPP-A , PAPPA1 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 5H9 |
| Isotype: | IgG2b |
| Immunogen: | Purified human PAPP-A/proMBP (heterotetrameric PAPP-A, htPAPP-A) complex. |
| Application: | ELISA, IP, WB |
Description
Description: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
Additional Text
Gene Name
PAPPA
Gene ID
5069
Molecular Weight
181
Purification
Protein A purified
Uniprot ID
Q13219
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
GTX10191 Datasheet
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