MIP3 beta antibody
Catalogue Number: GTX10389-GTX
| Manufacturer: | GeneTex |
| Preservative: | no preservative|No preservative |
| Molecular Weight: | 12 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | chemokine (C-C motif) ligand 19 , CKb11 , ELC , MIP3B , Scya19 , exodus-3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant mouse MIP-3β, expressed in Escherichia coli. |
| Application: | ICC, IF, WB, NT, Inh |
Description
Description: MIP3 chemokines are among many novel beta chemokines recently identified through bioinformatics in the Expressed Sequence Tag (EST) database. They are distantly related to other beta chemokines (20-30% aa sequence homology). MIP3 chemokines are useful probes for studying the biology of inflammation and cell migration. Their expression is strongly up-regulated by inflammatory signals and down-regulated by the antiinflammatory cytokine IL10. MIP3 genes do not share chromosomal locations with other beta chemokines that are mainly clustered on chromosome 17. MIP3 alpha is also known as LARC (liver and activation regulated chemokine) and as exodus. It is expressed predominately in lymph nodes, appendix, PBL, fetal liver, fetal lung and some cell lines. Synthetic or recombinant MIP3 alpha has been shown to be chemotactic for cultured human lymphocytes and to inhibit proliferation of myeloid progenitors in colony formation assays. MIP3 alpha binds to the chemokine receptor CCR6. The MIP3 alpha gene has been mapped to chromosome 2. MIP3 beta is also known as ELC (EBI1-1 ligand chemokine) and is constitutively expressed in various lymphoid tissues (thymus, lymph nodes, appendix and spleen). MIP3 beta is a chemoattractant for cultured human lymphcytes, dendritic cells, human Tlymphoblastoid CEM NKR2 and hemopoietic progenitor cells. It may be involved in G Protein activation in human NK cells. MIP3 beta is a unique functional ligand for CCR7. The MIP3 beta gene has been mapped to chormosome 9p13.
Additional Text
Uniprot ID
O70460
Purification
Affinity Purified
Gene ID
100039053; 24047
Gene Name
Ccl19, Gm2023
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
12
Application Notes
WB: 0.1-0.2 µg/ml. ICC/IF: 5-15 µg/ml. Neutralizing/Inhibition: 0.8-4 µg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX10389 Datasheet
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