EphB4 antibody
Catalogue Number: GTX10618-GTX
| Manufacturer: | GeneTex |
| Preservative: | no preservative|No preservative |
| Molecular Weight: | 109 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Eph receptor B4 , AI042935 , Htk , MDK2 , Myk1 , Tyro11 , b2b2412Clo |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | purified recombinant mouse EphB4 extracellular domain expressed in mouse NSO cells. |
| Application: | ELISA, FC, WB, DB, IHC, NT, Inh |
Description
Description: EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The Eph receptors and ephrin ligands display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands.Ephs and ephrins play a significant role in angiogenesis.
Additional Text
Gene Name
EPHB4
Uniprot ID
P54761
Purification
Affinity Purified
Gene ID
13846
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
109
Application Notes
WB: 0.1-0.2 µg/ml. IHC: 5-15 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX10618 Datasheet
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