NFkB p65 antibody

Catalogue Number: GTX107678-GTX

Manufacturer:GeneTex
Preservative:0.025% ProClin™ 300
Molecular Weight:60
Physical state:Liquid
Type:Polyclonal Primary Antibody - Unconjugated
Alias:RELA proto-oncogene, NF-kB subunit , CMCU , NFKB3 , p65
Shipping Condition:Dry Ice
Unit(s): 100 ul, 25 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human NFkB p65. The exact sequence is proprietary.
Application: ICC, IF, IHC-P, IP, WB, EMSA

Description

Description: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Additional Text

Gene Name

RELA

Gene ID

5970

Uniprot ID

Q04206

Molecular Weight

60

Concentration

1.46 mg/ml

Price
223.00


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