IL10 Receptor beta antibody

Catalogue Number: GTX10778-GTX

Manufacturer:	GeneTex
Preservative:	no preservative\|No preservative
Molecular Weight:	37
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	interleukin 10 receptor subunit beta , CDW210B , CRF2-4 , CRFB4 , D21S58 , D21S66 , IL-10R2
Shipping Condition:	Blue Ice
Unit(s):	25 ug
Host name:	Goat
Clone:
Isotype:	IgG
Immunogen:	Recombinant fragment (Human).
Application:	ELISA, FC, WB, NT, Inh

Overview
Datasheets

Description

Description: Interleukin 10, initially named cytokine synthesis inhibitory factor (CSIF), is a potent immunosuppressant of macrophage functions. IL10, a pleiotropic cytokine, exerts either immunostimulatory or immunosuppressive effects on a number of cell types, including Thy2 cells, activated fetal thymocytes, macrophages, keratinocytes, and LY-1 (CD5+) and normal B cells. IL10 stimulates the growth of stem cells, mast cells, and thymocytes and also enhances cytotoxic T cell development, costimulates B cell differentiation, and immunoglobulin secretion. Interleukin 10 binds specifically and with high affinity to cell surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. The human interleukin 10 receptor gene maps to chromosome 11q23.3.7

Additional Text

Gene Name

IL10RB

Uniprot ID

Q08334

Gene ID

3588

Purification

Affinity Purified

Molecular Weight

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX10778 Datasheet

Price

£499.00

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