Cytokeratin 4 antibody [6B10]

Catalogue Number: GTX11215-GTX

Manufacturer:	GeneTex
Preservative:	15 mM Sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	keratin 4 , CK-4 , CK4 , CYK4 , K4 , WSN1
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	6B10
Isotype:	IgG1
Immunogen:	cytokeratin from human esophagus.
Application:	ICC, IF, IHC-P, WB, IHC-Fr, DB

Overview
Datasheets

Description

Description: Intermediate filaments are abundant cytoplasmic structural proteins in most vertebrate cells. Cytokeratins, a group comprised of at least 29 different proteins are characteristic of epithelial and trichocytic cells. Cytokeratin 4 is a member of the type II, neutralto- basic subfamily. It is a 59 kD polypeptide differentially expressed in various human tissues. Cytokeratin 4 can be detected by biochemical or immunohistochemical means in adult non-cornified squamous epithelium such as that of the superficial and intermediate cells of the esophagus, exocervix, tongue, vagina, larynx,pharynx, epiglottis, and anus as well as in the superficial cells of the cornea. In addition, its presence was demonstrated in suprabasal cells of the urinary bladder transitional epithelium, in single cells and cell groups of sweat glands and prostatic ducts and in cylindrical ciliated bronchial cells. Cytokeratin 4 may be detected in squamous cell carcinomas derived from several non-cornified stratified epithelia. Monoclonal anti-cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal anti-Cytokeratin 4 is a chain specific antibody which may facilitate typing of normal, metaplastic and neoplastic cells.

Additional Text

Gene Name

KRT4

Gene ID

3851

Purification

Unpurified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

IHC-P: 1:300. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX11215 Datasheet

GTX11215 Reference

Price

£410.00

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