Muscleblind-like 1 antibody

Catalogue Number: GTX112624-GTX

Manufacturer:	GeneTex
Preservative:	0.01% Thimerosal
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	muscleblind like splicing regulator 1 , EXP , MBNL
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant protein encompassing a sequence within the center region of human Muscleblind-like 1. The exact sequence is proprietary.
Application:	ICC, IF, IP, WB

Overview
Datasheets

Description

Description: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.

Additional Text

Concentration

1 mg/ml

Molecular Weight

Gene Name

MBNL1

Uniprot ID

Q9NR56

Purification

Affinity Purified

Gene ID

4154

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX112624 Datasheet

GTX112624 Reference

Price

£285.00

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Quantity
Unit Size

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