beta Catenin antibody [15B8] (Cy3)

Catalogue Number: GTX11348-GTX

Manufacturer:	GeneTex
Preservative:	15 mM Sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	catenin beta 1 , CHBCAT
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	15B8
Isotype:	IgG1
Immunogen:	recombinant chicken β-catenin.
Application:	ICC, IF, WB

Overview
Datasheets

Description

Description: The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Additional Text

Gene Name

CTNNB1

Gene ID

395964

Purification

Purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Concentration

1 mg/ml

Application Notes

ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

GTX11348 Datasheet

Price

£410.00

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