4-1BBL / CD137L antibody [N2C3]
Catalogue Number: GTX117355-GTX
GTX117355 Image
GTX117355 Image
GTX117355 Image
TNFSF9 antibody [N2C3] immunoprecipitates TNFSF9 protein in IP experiments. IP samples: A549 membrane extract A. Control with 4 µg of preimmune Rabbit IgG B. Immunoprecipitation of TNFSF9 protein by 4 µg TNFSF9 antibody [N2C3] (GTX117355) 15 % SDS-PAGE The immunoprecipitated TNFSF9 protein was detected by TNFSF9 antibody [N2C3] (GTX117355) diluted at 1:500. [EasyBlot anti-rabbit IgG (GTX221666-01) was used as a secondary reagent]
GTX117355 Image
Sample (30 ug of whole cell lysate) A: HCT116 12% SDS PAGE GTX17355 diluted at 1:1000
| Manufacturer: | GeneTex |
| Preservative: | 0.01% Thimerosal|0.01% Thimerosal |
| Molecular Weight: | 27 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | TNF superfamily member 9 , 4-1BB-L , CD137L , TNLG5A |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant protein encompassing a sequence within the Extracellular domain of human TNFSF9. The exact sequence is proprietary. |
| Application: | IP, WB |
Description
Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Additional Text
Gene ID
8744
Gene Name
TNFSF9
Uniprot ID
P41273
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
27
Concentration
1 mg/ml
Application Notes
WB: 1:500-1:3000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX117355 Datasheet
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