Geminin antibody
Catalogue Number: GTX12147-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | geminin DNA replication inhibitor , Gem , MGORS6 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide: SSENKNLGGVTQES-C conjugated to KLH, corresponding to amino acids 72-85 of Human Geminin. |
| Application: | ICC, IF, IHC-P, WB |
Description
Description: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
Additional Text
Gene Name
GMNN
Molecular Weight
24
Uniprot ID
O75496
Concentration
0.1 mg/ml
Gene ID
51053
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: Use at a dilution of 1/500. Detects a band of approximately 33 kDa (predicted molecular weight: 23.5 kDa). Can be blocked with GTX12408 Geminin peptide . Optimal dilutions/concentrations should be determined by the end user.
GTX12147 Datasheet
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