ATR antibody
Catalogue Number: GTX128146-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.025% ProClin 300 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ATR. The exact sequence is proprietary. |
| Application: | ICC, IF, IHC-P, IP, WB |
Description
Description: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]
Additional Text
Concentration
1 mg/ml
Gene Name
ATR
Gene ID
545
Uniprot ID
Q13535
Purification
Affinity Purified
Molecular Weight
301
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500-1:3000. ICC/IF: 1:100-1:5000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
ATR antibody detects the serine/threonine-protein kinase ATR (Ataxia Telangiectasia and Rad3-related protein) (also known as FRAP-related protein 1 (FRP1)). ATR (301 kDa) is a key component of the DNA damage response machinery and is activated by ssDNA, leading to cell cycle arrest while DNA damage is repaired. It also plays a critical role in stabilizing the genome during DNA replication by preventing premature onset of mitosis. This ATR antibody is a cited rabbit polyclonal validated for multi
GTX128146 Datasheet
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