ATR (phospho Ser428) antibody

Catalogue Number: GTX133852-GTX

Manufacturer:	GeneTex
Preservative:	0.025% ProClin 300
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Carrier-protein conjugated synthetic peptide surrounding phospho Ser428 of human ATR. The exact sequence is proprietary.
Application:	ICC, IF, WB

Overview
Datasheets

Description

Description: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]

Additional Text

Gene Name

ATR

Gene ID

545

Uniprot ID

Q13535

Concentration

0.26 mg/ml

Purification

Affinity Purified

Modification

Phosphorylated, Ser428

Molecular Weight

301

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX133852 Datasheet

Price

£285.00

-

Quantity
Unit Size

Find out about delivery