CLOCK antibody

Catalogue Number: GTX134464-GTX

Manufacturer:GeneTex
Preservative:0.025% ProClin™ 300
Molecular Weight:95
Physical state:Liquid
Type:Polyclonal Primary Antibody - Unconjugated
Alias:clock circadian regulator , KAT13D , bHLHe8
Shipping Condition:Blue Ice
Unit(s): 100 ul, 25 ul, 10 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CLOCK. The exact sequence is proprietary.
Application: ICC, IF, WB

Description

Description: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Additional Text

Gene ID

9575

Gene Name

CLOCK

Uniprot ID

O15516

Molecular Weight

95

Concentration

0.57 mg/ml

Antibody Clonality

Polyclonal

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Gene Alias

clock circadian regulator , KAT13D , bHLHe8

Price
223.00


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