Talin-1 antibody
Catalogue Number: GTX134635-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.025% ProClin 300 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | talin 1 , ILWEQ , TLN , talin-1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant protein encompassing a sequence within the center region of human Talin-1. The exact sequence is proprietary. |
| Application: | ICC, IF, IHC-P, WB |
Description
Description: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Additional Text
Gene Name
TLN1
Gene ID
7094
Concentration
0.54 mg/ml
Uniprot ID
Q9Y490
Purification
Affinity Purified
Molecular Weight
270
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
Talin antibody recognizes the cytoskeletal component talin, a ~270 kDa protein involved in cell mechanotransduction that links the cytoskeleton to integrins. It forms an antiparallel homodimer and interacts with vinculin, actin, and integrins. Talin is incorporated very early in the cell-extracellular matrix (ECM) adhesion process.
GTX134635 Datasheet
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