Fas antibody [ZB4]
Catalogue Number: GTX13549-GTX
| Manufacturer: | GeneTex |
| Preservative: | No preservative |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Fas cell surface death receptor , ALPS1A , APO-1 , APT1 , CD95 , FAS1 , FASTM , TNFRSF6 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Mouse |
| Clone: | ZB4 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant full length protein (Human). |
| Application: | FACS, WB, IHC, NT, Blk, Inh, InVivoA |
Description
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Additional Text
Gene Name
FAS
Concentration
1 mg/ml
Gene ID
355
Uniprot ID
P25445
Purification
Protein A purified
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
38
Application Notes
FACS: Use at a concentration of 5 - 20 µg/ml. FuncS: Use at a concentration of 500 ng/ml to block the apoptotic activity other anti-CD95 antibodies. IHC: Use at an assay dependent dilution. WB: Use at a concentration of 5 µg/ml. Predicted molecular weight: 44 kDa. Optimal dilutions/concentrations should be determined by the end user.
GTX13549 Datasheet
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