Caspase 3 antibody [31A1067]

Catalogue Number: GTX13585-GTX

Manufacturer:	GeneTex
Preservative:	0.05% Sodium azide\|0.05% Sodium azide
Molecular Weight:	32
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	caspase 3 , CPP32 , CPP32B , SCA-1
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	31A1067
Isotype:	IgG1
Immunogen:	Full-length recombinant human caspase-3 protein was used as immunogen. The antibody recognizes an epitope in the large domain subunit of Caspase-3. As such it will recognize pro Caspase-3 and the large subunit cleavage fragment.
Application:	FC, ICC, IF, IHC-P, EM, WB, IHC-Fr, MS

Overview
Datasheets

Description

Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]

Additional Text

Gene Name

CASP3

Gene ID

836

Molecular Weight

Uniprot ID

P42574

Purification

Protein G purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Concentration

1 mg/ml

Application Notes

WB: 1 - 5 µg/ml. IHC-P: 1:10 - 1:500. IHC-Fr: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX13585 Datasheet

GTX13585 Reference

Price

£486.00

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