TRF2 antibody
Catalogue Number: GTX13589-GTX
GTX13589 Image
GTX13589 Image
GTX13589 Image
IHC-P analysis of human tonsil tissue using GTX13589 TRF2 antibody. Dilution : 15 µg/ml
GTX13589 Image
IP analysis of HL-60 cell lysate using GTX13589 TRF2 antibody. Lane 1 : IP with mouse anti-TRF2 antibody Lane 2 : IP with control mouse IgG Lane 3 : IP with goat anti-TRF2 antibody (GTX13589) Lane 4 : IP with pre-immune goat IgG
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide|0.05% Sodium azide |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Baculovirus expressed His-tagged whole length TRF2 protein was used for immunizing goat (NP_005643). |
| Application: | ICC, IF, IHC-P, IP, ChIP, WB |
Description
Description: TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Additional Text
Purification
Protein G purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Concentration
1 mg/ml
Application Notes
WB: 2 µg/ml. ICC/IF: 1:20 - 1:1000. IHC-P: 15 µg/ml. IP: 2 µg/ 10⁶ cells. ChIP assay: 1:20 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX13589 Datasheet
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