PGCB antibody

Catalogue Number: GTX14784-GTX

Manufacturer:GeneTex
Preservative:0.02% Sodium azide|0.02% Sodium azide
Molecular Weight:117
Physical state:Liquid
Type:Polyclonal Primary Antibody - Unconjugated
Alias:natriuretic peptide receptor 2 , AMDM , ANPRB , ANPb , ECDM , GUC2B , GUCY2B , NPRB , NPRBi , SNSK
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein.
Application: ELISA, ICC, IF, IP, WB, IHC

Description

Description: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

Additional Text

Gene ID

4882

Uniprot ID

P20594

Purification

Affinity Purified

Molecular Weight

117

Gene Name

NPR2

Antibody Clonality

Polyclonal

Concentration

0.75-1.20 mg/ml

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500. ICC/IF: 1:200. IP: 1:200. ELISA: 1:10000. IHC: 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.