ACE2 antibody

Catalogue Number: GTX15349-GTX

Manufacturer:GeneTex
Preservative:0.02% Sodium azide
Molecular Weight:92
Physical state:Liquid
Type:Polyclonal Primary Antibody - Unconjugated
Alias:angiotensin I converting enzyme 2 , ACEH
Shipping Condition:Dry Ice
Unit(s): 100 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.The immunogen is located within amino acids 150 - 200 of ACE2.
Application: ELISA, ICC, IF, IHC-P, WB

Description

Description: Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. ACE2 is restricted to the testis, heart, kidney and colon. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22. No cross reactivity to ACE1.

Additional Text

Uniprot ID

Q9BYF1

Concentration

1 mg/ml

Gene Name

ACE2

Gene ID

59272

Molecular Weight

92