ACE2 peptide (788-805)
Catalogue Number: GTX15352-GTX
| Manufacturer: | GeneTex |
| Shelf Life: | 12 months |
| Preservative: | 0.02% Sodium azide |
| Physical state: | Liquid |
| Type: | Peptide |
| Alias: | Angiotensin I Converting Enzyme 2 , Aceh , Ace2 |
| Shipping Condition: | Dry Ice |
| Unit(s): | 50 ug |
| Application: | NT, Inh, Ctrl |
Description
Description: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Additional Text
Gene Name
ACE2
Gene ID
59272
Concentration
0.2 mg/ml
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
For BL: Use at an assay dependent dilution. The peptide is used for blocking the activity of ACE2 antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C. Optimal dilutions/concentrations should be determined by the end user.
GTX15352 Datasheet
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