ATF6 blocking peptide
Catalogue Number: GTX15457-PEP-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Physical state: | Liquid |
| Type: | Blocking Peptides |
| Alias: | Activating Transcription Factor 6 , Achm7 , Atf6A , Atf6 |
| Shipping Condition: | Dry Ice |
| Unit(s): | 50 ug |
| Application: | NT, Inh |
Description
Description: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Additional Text
Gene Name
ATF6
Concentration
200 ug/ml
Gene ID
22926
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Short Description
ATF6 peptide is used for blocking the activity of ATF6 antibody (catalog number GTX15457).
Storage Note
Store as concentrated solution. Aliquot and store at -20C or below. Avoid freeze-thaw cycles.
GTX15457-PEP Datasheet
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