MTGR1 antibody
Catalogue Number: GTX16137-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.08% Sodium azide|0.08% Sodium azide |
| Molecular Weight: | 67 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CBFA2/RUNX1 translocation partner 2 , EHT , MTGR1 , ZMYND3 , p85 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Unfortunately, this information is considered to be commercially sensitive |
| Application: | WB |
Description
Description: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Additional Text
Gene Name
CBFA2T2
Gene ID
9139
Molecular Weight
67
Uniprot ID
O43439
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: Use at a concentration of 1 - 10 µg/ml. Predicted molecular weight: 67 kDa. Optimal dilutions/concentrations should be determined by the end user.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX16137 Datasheet
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