Bax antibody
Catalogue Number: GTX16143-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.08% Sodium azide|0.08% Sodium azide |
| Molecular Weight: | 21 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | BCL2 associated X, apoptosis regulator , BCL2L4 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 125 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide: LTTAPAPPSLPPATPLGPWAFWSRSQWC, corresponding to amino acids 172-199 of Human beta Bax. |
| Application: | IP |
Description
Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
Additional Text
Gene Name
BAX
Gene ID
581
Uniprot ID
Q07812
Purification
Protein G purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Concentration
1 mg/ml
Application Notes
IP: Use at an assay dependent dilution. Is unsuitable for WB. Will not detect denatured protein. Optimal dilutions/concentrations should be determined by the end user.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX16143 Datasheet
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