Glucocorticoid Receptor beta antibody

Catalogue Number: GTX16319-GTX

Manufacturer:	GeneTex
Preservative:	0.05% Sodium azide\|0.05% Sodium azide
Molecular Weight:	86
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	nuclear receptor subfamily 3 group C member 1 , GCCR , GCR , GCRST , GR , GRL
Shipping Condition:	Blue Ice
Unit(s):	50 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Synthetic Peptide: N(728) V M W L K P E S T S H T L I(742) C
Application:	FC, ICC, IF, IP, WB, IHC, EMSA

Overview
Datasheets

Description

Description: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Additional Text

Gene ID

2908

Gene Name

NR3C1

Uniprot ID

P04150

Molecular Weight

Purification

Unpurified

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500. ICC/IF: 1:1,500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX16319 Datasheet

GTX16319 Reference

Price

£410.00

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Quantity
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