RIP2 antibody [Nick-1]
Catalogue Number: GTX17328-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Molecular Weight: | 61 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | receptor interacting serine/threonine kinase 2 , CARD3 , CARDIAK , CCK , GIG30 , RICK , RIP2 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 50 ug |
| Host name: | Rat |
| Clone: | Nick-1 |
| Isotype: | IgG2a |
| Immunogen: | Recombinant fragment, corresponding to N terminal amino acids 1-322 of Human RIP2. |
| Application: | WB |
Description
Description: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD containing serine/threonine kinase RIP regulates Fas induced apoptosis. A novel CARD containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP like interacting CLARP kinase, receptor interacting protein 2, and CARD containing ICE associated kinase, respectively. RICK contains an N terminal kinase catalytic domain and a C terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF kB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase 1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced apoptosis and that is involved in the generation of proinflammatory cytokine IL1b. The messenger RNA of RICK is expressed in multiple human tissues.
Additional Text
Gene Name
RIPK2
Uniprot ID
O43353
Gene ID
8767
Molecular Weight
61
Purification
Purified
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:1,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C.
GTX17328 Datasheet
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