c-Myc antibody [33]
Catalogue Number: GTX17356-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.08% Sodium azide|0.08% Sodium azide |
| Molecular Weight: | 49 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | MYC proto-oncogene, bHLH transcription factor , MRTL , MYCC , bHLHe39 , c-Myc |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 33 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant full length protein (Human). |
| Application: | ICC, IF, IP, WB, IHC-Fr |
Description
Description: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Additional Text
Gene Name
MYC
Gene ID
4609
Uniprot ID
P01106
Molecular Weight
49
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Concentration
1 mg/ml
Application Notes
IF: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. Myc is a labile protein, thereforepreotease inhibitors should be used at all times. IP (with and without SDS): Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 49, 64 & 67 kD (predicted molecular weight: 49 kD). 64 and 67kD forms are phosphophorylated. Optimal dilutions/concentrations should be determined by the end user.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX17356 Datasheet
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