Laminin alpha 3B antibody [F7]

Catalogue Number: GTX17684-GTX

Manufacturer:	GeneTex
Preservative:	no preservative\|No preservative
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	F7
Isotype:	IgG1
Immunogen:	Recombinant human laminin-alpha 3B N-term ~190 kDa fragment
Application:	AP, ELISA, IHC-P, IP, WB, IHC-Fr

Overview
Datasheets

Additional Text

Purification

Unpurified

Antibody Clonality

Monoclonal

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Application Notes

WB: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Short Description

Laminins, which consist of three subunits called alpha, beta and gamma chains, are major cell-adhesive components of extracellular matrix, especially basement membranes (BMs). The laminin family is constituted of over 15 isoforms, and each member is expressed in a tissue-specific manner and plays a differential role in each tissue. In the case of laminin alpha 3 chain, there are two splicing variants, the truncated form alpha 3A and the full-length alpha 3B. Laminin-3B32 (Lm3B32) (formerly, laminin-5B) is composed of alpha 3B, beta 3 and gamma 2 chains and less widely expressed than laminin-3A32. Although laminin-3B32 shows higher cell adhesion activity than laminin-3A32 in vitro, differences of biological functions between two laminins remain to be clarified. Recent studies identified laminin-3B11 (Lm3B11) as a new alpha 3B-type laminin. Laminin-3B11 is localized in vascular basement membranes in normal tissues, but this expression is down-regulated in cancer tissues.Laminin-3B11 stimulates microvascular endothelial cells to extend lamelliopodial protrusions. This antibody (clone F7) detects laiminin-3B32 in the basement membranes of normal epithelial tissues and of relatively benign or differentiated carcinomas and laminin-3B11 in normal vascular basement membranes. This antibody is a powerful tool to detect laminin alpha 3B isoform and investigate its fundamental functions in epithelial and vascular basement membranes.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX17684 Datasheet

GTX17684 Reference

Price

£499.00

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