Presenilin 2 antibody
Catalogue Number: GTX18041-GTX
| Manufacturer: | GeneTex |
| Molecular Weight: | 50 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | Two synthetic peptides (Human). |
| Application: | ELISA, WB, IHC |
Description
Description: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
Additional Text
Gene Name
PSEN2
Uniprot ID
P49810
Gene ID
5664
Molecular Weight
50
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Concentration
1 mg/ml
Application Notes
ELISA: 1/1000 - 1/4000. IHC: Use at an assay dependent dilution. WB: 1/1000 - 1/4000. Predicted molecular weight: 54 kDa. To minimize background staining, we suggest using higher content of detergent (Tween-20) in dilutions of the antibody and washing. Optimal dilutions/concentrations should be determined by the end user.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX18041 Datasheet
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