TBP antibody [1TBP18]

Catalogue Number: GTX20818-GTX

Manufacturer:	GeneTex
Preservative:	no preservative\|No preservative
Molecular Weight:	38
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	GTF2D , GTF2D1 , HDL4 , SCA17 , TATAbox binding protein , TBP , TFIID , TATA binding protein TBP , TATA box binding protein , TATA-box binding protein
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	1TBP18
Isotype:	IgG1
Immunogen:	Recombinant human TBP.
Application:	ICC, IF, IP, WB, EMSA

Overview
Datasheets

Description

Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

Additional Text

Gene Name

TBP

Gene ID

6908

Uniprot ID

P20226

Purification

Protein G purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX20818 Datasheet

GTX20818 Reference

Price

£374.00

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Quantity
Unit Size

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