alpha Synuclein antibody [4B12]
Catalogue Number: GTX21904-GTX
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IHC analysis of the cortical Lewy body using alpha Synuclein antibody [4B12].
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The data was published in the journal Oncotarget in 2017. PMID: 27845893
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The data was published in the journal Sci Rep in 2017. PMID: 29184069
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The data was published in the journal Mol Neurodegener in 2017. PMID: 28676095
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The data was published in the journal Acta Neuropathol Commun in 2018.PMID: 29298733
| Manufacturer: | GeneTex |
| Preservative: | 0.1% Sodium azide |
| Molecular Weight: | 14 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | synuclein alpha , NACP , PARK1 , PARK4 , PD1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4B12 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human alpha synuclein produced in E. coli. |
| Application: | ELISA, IHC-P, WB, IHC-Fr, DB, IHC |
Description
Description: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Additional Text
Gene ID
6622
Gene Name
SNCA
Uniprot ID
P37840
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
14
Concentration
1 mg/ml
Application Notes
Dot: Use at a dilution of 1/100 - 1/10000. ELISA: Use at an assay dependent dilution. IHC-P: Use at a dilution of 1/100 - 1/1000. Antigen retrieval is not essential but may optimise staining. IHC-Fr: Use at a dilution of 1/100 - 1/1000. WB: Use at a dilution of 1/100 - 1/10000. Predicted molecular weight: 16 kDa. Optimal dilutions/concentrations should be determined by the end user.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX21904 Datasheet
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