Her2 / ErbB2 peptide

Catalogue Number: GTX22429-GTX

Manufacturer:	GeneTex
Shelf Life:	12 months
Preservative:	0.1% Sodium azide
Molecular Weight:	138
Physical state:	Liquid
Type:	Peptide
Alias:	erb-b2 receptor tyrosine kinase 2 , CD340 , HER-2 , HER-2/neu , HER2 , MLN 19 , NEU , NGL , TKR1
Shipping Condition:	Blue Ice
Unit(s):	500 ul
Application:	IP

Overview
Datasheets

Description

Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Additional Text

Gene ID

2064

Gene Name

ERBB2

Uniprot ID

P04626

Concentration

0.2 mg/ml

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

Blocking peptide for rabbit Polyclonal antibody to Her2 / ErbB2(GTX22428).

Storage Note

Store this product at 4C, DO NOT FREEZE. The product is stable for one year from the date of shipment.

GTX22429 Datasheet

Price

£154.00

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Quantity
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