Androgen Receptor antibody [AN1-15]
Catalogue Number: GTX22742-GTX
GTX22742 Image
GTX22742 Image
GTX22742 Image
GTX22742 Image
IHC-P analysis of human prostate tissue using GTX22742 Androgen Receptor antibody [AN1-15]. A : isotype control B : Primary antibody C : Primary antibody with magnified section Antigen retrieval : HEIR with a buffer (pH 6.2) Dilution : 2 µg/ml
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WB analysis of 25 ug of T47D (lane 1), LNCaP (lane 2) and NIH-3T3 (lane 3) lysates using GTX22742 Androgen Receptor antibody [AN1-15]. Dilution : 1:100
GTX22742 Image
IHC-P analysis of primate brain tissue using GTX22742 Androgen Receptor antibody [AN1-15].
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide|0.05% Sodium azide |
| Molecular Weight: | 99 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | androgen receptor , AIS , AR8 , DHTR , HUMARA , HYSP1 , KD , NR3C4 , SBMA , SMAX1 , TFM |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rat |
| Clone: | AN1-15 |
| Isotype: | IgG |
| Immunogen: | A fusion protein corresponding to residues 331-572 of human androgen receptor. |
| Application: | ICC, IF, IHC-P, IP, WB, IHC-Fr, IHC, EMSA |
Description
Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Additional Text
Gene Name
AR
Gene ID
367
Uniprot ID
P10275
Molecular Weight
99
Purification
Protein A purified
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:50-1:500. ICC/IF: 5 µg/ml. IHC-P: 2-4 µg/mL. IHC-Fr: 2-4 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX22742 Datasheet
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