Ku70 + Ku80 antibody [162]
Catalogue Number: GTX23108-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.09% Sodium azide |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CTC75 , FLJ39089 , CTCBF , KARP-1 , G22P1 , KARP1 , KU70 , KU80 , ML8 , KUB2 , TLAA , Ku86 , NFIV , KARP 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ul |
| Host name: | Mouse |
| Clone: | 162 |
| Isotype: | IgG2a |
| Immunogen: | Human B cell nuclei from plasmacytoid 2p68 cells. |
| Application: | FACS, ICC, IF, IHC-P, IP, WB, EMSA, RIP |
Description
Description: The Ku autoantigen is a heterodimer of 70 kDa (p70) and ~80 kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Additional Text
Concentration
0.2 mg/ml
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
Flow Cytometry / Immunofluorescence: assay dependent. Immunoprecipitation (with protein A): use at a concentration of 2µg/mg protein lysate. Immunohistology (formalin fixed paraffin embedded): use at a concentration 1 - 2µg/ml for 30 min at RT (antigen retrieval is not required). Optimal dilutions / concentrations should be determined by the end user. This antibody is not suitable for Western blot.
GTX23108 Datasheet
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