Rabbit Anti-Human IgA antibody (FITC)

Catalogue Number: GTX24219-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Physical state:	Liquid
Type:	Polyclonal Secondary Antibody - Conjugated
Alias:	immunoglobulin heavy locus , IGD1 , IGH.1@ , IGH@ , IGHD@ , IGHDY1 , IGHJ , IGHJ@ , IGHV , IGHV@
Shipping Condition:	Blue Ice
Unit(s):	500 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	IgA isolated from human serum.
Application:	IHC-P

Overview
Datasheets

Description

Description: Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Dec 2017]

Additional Text

Gene ID

3492

Purification

Purified

Gene Name

IGH

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. Protect from light.

GTX24219 Datasheet

Price

£302.00

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